藥物交互作用
Apraclonidine + Selegiline
嚴重程度: 嚴重
Apraclonidine and Selegiline: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Apraclonidine is an alpha-2 agonist, and labeling advises against its use with MAO inhibitors because of a possible rise in blood pressure. The pharmacological basis is not fully clear, and exposure is low with ophthalmic use, but the labeling warning remains.
用白話說明這項交互作用的意義
Apraclonidine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Selegiline belongs to Central Nervous System.
為什麼會發生
Mechanism is not established; possible altered catecholamine handling with MAO inhibition affecting blood pressure.
處置方式
Avoid the combination where possible and choose another ocular hypotensive agent. If apraclonidine is essential, monitor blood pressure closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Selegiline 的其他交互作用
Apraclonidine 的其他交互作用
常見問題
Can I take Apraclonidine with Selegiline?
MediHelp rates the interaction as major. Apraclonidine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine is an alpha-2 agonist, and labeling advises against its use with MAO inhibitors because of a possible rise in blood pressure. The pharmacological basis is not fully clear, and exposure is low with ophthalmic use, but the labeling warning remains.
How serious is the interaction between Apraclonidine and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another ocular hypotensive agent. If apraclonidine is essential, monitor blood pressure closely.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
