藥物交互作用
Amiodarone + Bosutinib
嚴重程度: 嚴重
Amiodarone and Bosutinib: major interaction.
最後更新
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摘要
Amiodarone inhibits CYP3A4 and P-glycoprotein and may raise bosutinib concentrations, increasing gastrointestinal, hepatic and hematologic toxicity. Both drugs may also affect QT interval.
用白話說明這項交互作用的意義
Amiodarone and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Bosutinib belongs to Oncology.
為什麼會發生
Inhibition of CYP3A4 and P-glycoprotein by amiodarone, with possible additive QT effects.
處置方式
Avoid the combination if possible. If used, monitor liver tests, blood counts, ECG and bosutinib adverse effects and consider dose reduction.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Bosutinib 的其他交互作用
常見問題
Can I take Amiodarone with Bosutinib?
MediHelp rates the interaction as major. Amiodarone and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits CYP3A4 and P-glycoprotein and may raise bosutinib concentrations, increasing gastrointestinal, hepatic and hematologic toxicity. Both drugs may also affect QT interval.
How serious is the interaction between Amiodarone and Bosutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor liver tests, blood counts, ECG and bosutinib adverse effects and consider dose reduction.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
