藥物交互作用
Aprepitant + Mitotane
嚴重程度: 嚴重
Aprepitant and Mitotane: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Mitotane is a potent CYP3A4 inducer with a long half-life and can markedly reduce aprepitant concentrations. This may cause loss of antiemetic protection for weeks after mitotane exposure.
用白話說明這項交互作用的意義
Aprepitant and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Mitotane belongs to Oncology.
為什麼會發生
Mitotane induces CYP3A4, increasing aprepitant clearance.
處置方式
Avoid relying on aprepitant for emetic prophylaxis; use alternative antiemetics such as a 5-HT3 antagonist with dexamethasone adjusted for induction. Monitor for breakthrough vomiting.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Aprepitant 的其他交互作用
Mitotane 的其他交互作用
常見問題
Can I take Aprepitant with Mitotane?
MediHelp rates the interaction as major. Aprepitant and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a potent CYP3A4 inducer with a long half-life and can markedly reduce aprepitant concentrations. This may cause loss of antiemetic protection for weeks after mitotane exposure.
How serious is the interaction between Aprepitant and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid relying on aprepitant for emetic prophylaxis; use alternative antiemetics such as a 5-HT3 antagonist with dexamethasone adjusted for induction. Monitor for breakthrough vomiting.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
