藥物交互作用
Doravirine + Mitotane
嚴重程度: 禁忌併用
Doravirine and Mitotane: contraindicated interaction.
最後更新
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摘要
Mitotane is a long-acting enzyme inducer and is expected to reduce doravirine levels substantially. The induction can persist for weeks after mitotane is stopped, creating a risk of virologic failure.
用白話說明這項交互作用的意義
Doravirine and Mitotane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doravirine belongs to Anti Virals; Mitotane belongs to Oncology.
為什麼會發生
Mitotane induces CYP3A4, increasing doravirine metabolism.
處置方式
Avoid coadministration and choose an antiretroviral regimen not dependent on CYP3A. Allow for an extended washout of mitotane before using doravirine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Doravirine 的其他交互作用
Mitotane 的其他交互作用
常見問題
Can I take Doravirine with Mitotane?
MediHelp rates the interaction as contraindicated. Doravirine and Mitotane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mitotane is a long-acting enzyme inducer and is expected to reduce doravirine levels substantially. The induction can persist for weeks after mitotane is stopped, creating a risk of virologic failure.
How serious is the interaction between Doravirine and Mitotane?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and choose an antiretroviral regimen not dependent on CYP3A. Allow for an extended washout of mitotane before using doravirine.
What other medicines interact with Doravirine?
MediHelp also lists interactions of Doravirine with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Doravirine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
