藥物交互作用
Arsenic trioxide + Primaquine
嚴重程度: 嚴重
Arsenic trioxide and Primaquine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and primaquine has been associated with QT prolongation. The combination may raise the risk of serious arrhythmia.
用白話說明這項交互作用的意義
Arsenic trioxide and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Primaquine belongs to Anti Parasitic.
為什麼會發生
Additive prolongation of cardiac repolarization.
處置方式
Avoid if possible and use alternative antimalarial therapy. If needed, monitor ECG and correct potassium and magnesium.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Primaquine 的其他交互作用
Arsenic trioxide 的其他交互作用
常見問題
Can I take Arsenic trioxide with Primaquine?
MediHelp rates the interaction as major. Arsenic trioxide and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and primaquine has been associated with QT prolongation. The combination may raise the risk of serious arrhythmia.
How serious is the interaction between Arsenic trioxide and Primaquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use alternative antimalarial therapy. If needed, monitor ECG and correct potassium and magnesium.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
