藥物交互作用
Pimozide + Primaquine
嚴重程度: 禁忌併用
Pimozide and Primaquine: contraindicated interaction.
最後更新
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摘要
Both drugs can prolong the QT interval, and pimozide carries a notable risk of torsades de pointes. Giving them together raises the chance of a life-threatening ventricular arrhythmia.
用白話說明這項交互作用的意義
Pimozide and Primaquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
為什麼會發生
Additive pharmacodynamic QT prolongation through cardiac repolarization (potassium channel) blockade.
處置方式
Avoid the combination and choose an alternative antimalarial for radical cure if pimozide is required. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Primaquine 的其他交互作用
Pimozide 的其他交互作用
常見問題
Can I take Pimozide with Primaquine?
MediHelp rates the interaction as contraindicated. Pimozide and Primaquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and pimozide carries a notable risk of torsades de pointes. Giving them together raises the chance of a life-threatening ventricular arrhythmia.
How serious is the interaction between Pimozide and Primaquine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antimalarial for radical cure if pimozide is required. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before treatment.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Primaquine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
