藥物交互作用

Bedaquiline + Primaquine

嚴重程度: 嚴重

Bedaquiline and Primaquine: major interaction.

最後更新 29 十月 2026 來源: US FDA label

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摘要

Bedaquiline carries a QT prolongation warning, and primaquine may add to this effect. The combination may increase the risk of torsades de pointes.

用白話說明這項交互作用的意義

Bedaquiline and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bedaquiline belongs to Anti Bacterial; Primaquine belongs to Anti Parasitic.

證據等級: Low

為什麼會發生

Additive prolongation of ventricular repolarization.

處置方式

Monitor ECG at baseline and during treatment, and keep potassium, magnesium and calcium normal. Consider alternatives to primaquine if QTc rises markedly.

可向藥師詢問的問題

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

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建立帳號並開始 Pro+ 試用，即可解鎖 Bedaquiline 與 Primaquine 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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參考資料

Primaquine Phosphate - FDA drug label (DailyMed) - section 7 Drug Interactions (class statement: drugs that prolong the QT interval; "If Primaquine phosphate Tablets are used concomitantly with other drugs that prolong the QT interval, close and frequent electrocardiogram monitoring is advised") — DailyMed (FDA label)

常見問題

Can I take Bedaquiline with Primaquine?

MediHelp rates the interaction as major. Bedaquiline and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline carries a QT prolongation warning, and primaquine may add to this effect. The combination may increase the risk of torsades de pointes.

How serious is the interaction between Bedaquiline and Primaquine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG at baseline and during treatment, and keep potassium, magnesium and calcium normal. Consider alternatives to primaquine if QTc rises markedly.

What other medicines interact with Primaquine?

MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.

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摘要