藥物交互作用
Artesunate + Phenytoin
嚴重程度: 中度
Artesunate and Phenytoin: moderate interaction.
最後更新
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摘要
Phenytoin induces UGT enzymes that convert active dihydroartemisinin to its glucuronide. Exposure to the active metabolite may fall, potentially reducing antimalarial efficacy.
用白話說明這項交互作用的意義
Artesunate and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Phenytoin belongs to Central Nervous System.
為什麼會發生
UGT induction by phenytoin increases clearance of dihydroartemisinin, the active artesunate metabolite.
處置方式
Monitor for treatment failure and parasitological response in severe malaria. Consider an alternative anticonvulsant if feasible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Phenytoin 的其他交互作用
Artesunate 的其他交互作用
常見問題
Can I take Artesunate with Phenytoin?
MediHelp rates the interaction as moderate. Artesunate and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces UGT enzymes that convert active dihydroartemisinin to its glucuronide. Exposure to the active metabolite may fall, potentially reducing antimalarial efficacy.
How serious is the interaction between Artesunate and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure and parasitological response in severe malaria. Consider an alternative anticonvulsant if feasible.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
