藥物交互作用
Artesunate + Regorafenib
嚴重程度: 中度
Artesunate and Regorafenib: moderate interaction.
最後更新
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摘要
Regorafenib may raise exposure to dihydroartemisinin, the active metabolite of artesunate, because it inhibits UGT1A9 which clears this metabolite. Higher levels could increase artesunate-related adverse effects such as hematologic toxicity and liver enzyme elevations.
用白話說明這項交互作用的意義
Artesunate and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Regorafenib belongs to Oncology.
為什麼會發生
Regorafenib inhibits UGT-mediated glucuronidation of dihydroartemisinin, reducing its clearance.
處置方式
Monitor blood counts and liver function when artesunate is given to a patient on regorafenib. Watch for signs of increased artesunate toxicity.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Regorafenib 的其他交互作用
Artesunate 的其他交互作用
常見問題
Can I take Artesunate with Regorafenib?
MediHelp rates the interaction as moderate. Artesunate and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may raise exposure to dihydroartemisinin, the active metabolite of artesunate, because it inhibits UGT1A9 which clears this metabolite. Higher levels could increase artesunate-related adverse effects such as hematologic toxicity and liver enzyme elevations.
How serious is the interaction between Artesunate and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver function when artesunate is given to a patient on regorafenib. Watch for signs of increased artesunate toxicity.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
