藥物交互作用
Artesunate + Carbamazepine
嚴重程度: 中度
Artesunate and Carbamazepine: moderate interaction.
最後更新
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摘要
Carbamazepine induces UGT and CYP enzymes that handle artesunate and its active metabolite dihydroartemisinin. Exposure to the active metabolite may fall, raising the risk of treatment failure in malaria.
用白話說明這項交互作用的意義
Artesunate and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Carbamazepine belongs to Central Nervous System.
為什麼會發生
Carbamazepine induces UGT (and CYP2A6/CYP3A4) metabolism of artesunate and dihydroartemisinin.
處置方式
Monitor parasitological and clinical response closely, particularly in severe malaria. Consider an alternative antiseizure drug if prolonged therapy is needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Carbamazepine 的其他交互作用
Artesunate 的其他交互作用
常見問題
Can I take Artesunate with Carbamazepine?
MediHelp rates the interaction as moderate. Artesunate and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces UGT and CYP enzymes that handle artesunate and its active metabolite dihydroartemisinin. Exposure to the active metabolite may fall, raising the risk of treatment failure in malaria.
How serious is the interaction between Artesunate and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor parasitological and clinical response closely, particularly in severe malaria. Consider an alternative antiseizure drug if prolonged therapy is needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
