藥物交互作用
Artesunate + Eltrombopag
嚴重程度: 中度
Artesunate and Eltrombopag: moderate interaction.
最後更新
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摘要
Artesunate is converted to dihydroartemisinin (DHA), which is cleared by glucuronidation through UGT1A9 and UGT2B7. Eltrombopag inhibits UGT enzymes in vitro, so DHA exposure could rise, with possible increased adverse effects.
用白話說明這項交互作用的意義
Artesunate and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Eltrombopag belongs to Miscellaneous.
為什麼會發生
Eltrombopag inhibits UGT enzymes in vitro and may reduce glucuronidation of the active metabolite DHA.
處置方式
Monitor for artesunate adverse effects such as hemolysis and hepatic changes, and monitor platelet counts and liver tests. No empirical dose change is recommended.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Eltrombopag 的其他交互作用
Artesunate 的其他交互作用
常見問題
Can I take Artesunate with Eltrombopag?
MediHelp rates the interaction as moderate. Artesunate and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artesunate is converted to dihydroartemisinin (DHA), which is cleared by glucuronidation through UGT1A9 and UGT2B7. Eltrombopag inhibits UGT enzymes in vitro, so DHA exposure could rise, with possible increased adverse effects.
How serious is the interaction between Artesunate and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for artesunate adverse effects such as hemolysis and hepatic changes, and monitor platelet counts and liver tests. No empirical dose change is recommended.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
