藥物交互作用
Articaine + Nadolol
嚴重程度: 中度
Articaine and Nadolol: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Articaine is formulated with epinephrine, and unopposed alpha stimulation in a patient on a nonselective beta-blocker can cause hypertension with reflex bradycardia. The effect is usually transient but can be significant.
用白話說明這項交互作用的意義
Articaine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Articaine belongs to Central Nervous System; Nadolol belongs to Cardiovascular.
為什麼會發生
Nonselective beta-blockade leaves epinephrine's alpha-mediated vasoconstriction unopposed.
處置方式
Do not stop nadolol before dental anesthesia; use the minimum epinephrine-containing dose with aspiration and monitor blood pressure and heart rate.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Nadolol 的其他交互作用
Articaine 的其他交互作用
常見問題
Can I take Articaine with Nadolol?
MediHelp rates the interaction as moderate. Articaine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Articaine is formulated with epinephrine, and unopposed alpha stimulation in a patient on a nonselective beta-blocker can cause hypertension with reflex bradycardia. The effect is usually transient but can be significant.
How serious is the interaction between Articaine and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not stop nadolol before dental anesthesia; use the minimum epinephrine-containing dose with aspiration and monitor blood pressure and heart rate.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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