藥物交互作用
Articaine + Timolol
嚴重程度: 中度
Articaine and Timolol: moderate interaction.
最後更新
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摘要
Dental articaine is usually given with epinephrine. In patients on nonselective beta-blockers, unopposed alpha stimulation by epinephrine can cause hypertension with reflex bradycardia.
用白話說明這項交互作用的意義
Articaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Articaine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
為什麼會發生
Timolol blocks beta-2 mediated vasodilation, leaving epinephrine's alpha-mediated vasoconstriction unopposed.
處置方式
Do not stop the beta-blocker before the procedure. Use the minimum effective epinephrine dose with aspiration to avoid intravascular injection, and monitor blood pressure and heart rate.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Timolol 的其他交互作用
Articaine 的其他交互作用
常見問題
Can I take Articaine with Timolol?
MediHelp rates the interaction as moderate. Articaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dental articaine is usually given with epinephrine. In patients on nonselective beta-blockers, unopposed alpha stimulation by epinephrine can cause hypertension with reflex bradycardia.
How serious is the interaction between Articaine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not stop the beta-blocker before the procedure. Use the minimum effective epinephrine dose with aspiration to avoid intravascular injection, and monitor blood pressure and heart rate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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