藥物交互作用
Articaine + Propranolol
嚴重程度: 中度
Articaine and Propranolol: moderate interaction.
最後更新
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摘要
Articaine is formulated with epinephrine, and non-selective beta-blockade leaves alpha effects unopposed. This can cause marked hypertension with reflex bradycardia.
用白話說明這項交互作用的意義
Articaine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Articaine belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
為什麼會發生
Propranolol blocks beta-2 vasodilation, leaving epinephrine alpha-mediated vasoconstriction unopposed.
處置方式
Do not stop propranolol before dental anesthesia; use the lowest effective epinephrine dose with careful aspiration and monitor blood pressure and heart rate.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Propranolol 的其他交互作用
Articaine 的其他交互作用
常見問題
Can I take Articaine with Propranolol?
MediHelp rates the interaction as moderate. Articaine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Articaine is formulated with epinephrine, and non-selective beta-blockade leaves alpha effects unopposed. This can cause marked hypertension with reflex bradycardia.
How serious is the interaction between Articaine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not stop propranolol before dental anesthesia; use the lowest effective epinephrine dose with careful aspiration and monitor blood pressure and heart rate.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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