藥物交互作用
Atazanavir + Brentuximab
嚴重程度: 中度
Atazanavir and Brentuximab: moderate interaction.
最後更新
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摘要
Atazanavir is a strong CYP3A4 inhibitor and can raise exposure to the cytotoxic payload (MMAE) released from brentuximab vedotin. This may increase the risk of neutropenia and peripheral neuropathy.
用白話說明這項交互作用的意義
Atazanavir and Brentuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Brentuximab belongs to Oncology.
為什麼會發生
Inhibition of CYP3A4 reduces metabolism of MMAE, the active cytotoxic component of brentuximab vedotin.
處置方式
Monitor blood counts and neuropathy symptoms closely during co-treatment. Consider an alternative antiretroviral without strong CYP3A4 inhibition if toxicity develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Brentuximab 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Brentuximab?
MediHelp rates the interaction as moderate. Atazanavir and Brentuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir is a strong CYP3A4 inhibitor and can raise exposure to the cytotoxic payload (MMAE) released from brentuximab vedotin. This may increase the risk of neutropenia and peripheral neuropathy.
How serious is the interaction between Atazanavir and Brentuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms closely during co-treatment. Consider an alternative antiretroviral without strong CYP3A4 inhibition if toxicity develops.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
