藥物交互作用
Atenolol + Ponesimod
嚴重程度: 嚴重
Atenolol and Ponesimod: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Ponesimod lowers heart rate at treatment initiation, and beta-blockers add to this effect, raising the risk of symptomatic bradycardia and AV conduction delay.
用白話說明這項交互作用的意義
Atenolol and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol belongs to Cardiovascular; Ponesimod belongs to Central Nervous System.
為什麼會發生
Additive negative chronotropic effects of S1P receptor modulation and beta-blockade.
處置方式
Check resting heart rate and ECG before starting ponesimod, and consider an alternative to the beta-blocker if heart rate is low, following the labeled titration.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atenolol 的其他交互作用
Ponesimod 的其他交互作用
常見問題
Can I take Atenolol with Ponesimod?
MediHelp rates the interaction as major. Atenolol and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ponesimod lowers heart rate at treatment initiation, and beta-blockers add to this effect, raising the risk of symptomatic bradycardia and AV conduction delay.
How serious is the interaction between Atenolol and Ponesimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check resting heart rate and ECG before starting ponesimod, and consider an alternative to the beta-blocker if heart rate is low, following the labeled titration.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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