藥物交互作用
Avanafil + Nitroglycerin
嚴重程度: 禁忌併用
Avanafil and Nitroglycerin: contraindicated interaction.
最後更新
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摘要
Both avanafil and nitroglycerin relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
用白話說明這項交互作用的意義
Avanafil and Nitroglycerin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Nitroglycerin belongs to Cardiovascular.
為什麼會發生
PDE5 inhibition potentiates NO/cGMP vasodilation
處置方式
Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Nitroglycerin 的其他交互作用
Avanafil 的其他交互作用
常見問題
Can I take Avanafil with Nitroglycerin?
MediHelp rates the interaction as contraindicated. Avanafil and Nitroglycerin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both avanafil and nitroglycerin relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
How serious is the interaction between Avanafil and Nitroglycerin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Riociguat, Sildenafil, Tadalafil. The full list is on the Nitroglycerin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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