藥物交互作用
Nitroglycerin + Tadalafil
嚴重程度: 禁忌併用
Nitroglycerin and Tadalafil: contraindicated interaction.
最後更新 來源: US FDA label
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摘要
Tadalafil potentiates the hypotensive effect of nitrates and the combination can cause severe, potentially fatal hypotension, syncope or myocardial ischaemia. Because of tadalafil's long half-life, the risk persists for a prolonged period after a dose. Use is contraindicated in labeling.
用白話說明這項交互作用的意義
Nitroglycerin and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nitroglycerin belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
為什麼會發生
PDE5 inhibition prevents cGMP breakdown while nitroglycerin raises cGMP via nitric oxide, producing exaggerated vasodilation.
處置方式
Do not use nitrates in patients who have taken tadalafil in the previous 48 hours. If a nitrate is needed urgently after that interval, use it only under close medical supervision.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
參考資料
- Cialis (tadalafil) Prescribing Information - Contraindications — FDA Label
- Cialis SmPC - Contraindications — EMA SmPC
Tadalafil 的其他交互作用
Nitroglycerin 的其他交互作用
常見問題
Can I take Nitroglycerin with Tadalafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil potentiates the hypotensive effect of nitrates and the combination can cause severe, potentially fatal hypotension, syncope or myocardial ischaemia. Because of tadalafil's long half-life, the risk persists for a prolonged period after a dose. Use is contraindicated in labeling.
How serious is the interaction between Nitroglycerin and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use nitrates in patients who have taken tadalafil in the previous 48 hours. If a nitrate is needed urgently after that interval, use it only under close medical supervision.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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