藥物交互作用
Dihydroergotamine + Nitroglycerin
嚴重程度: 嚴重
Dihydroergotamine and Nitroglycerin: major interaction.
最後更新
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摘要
Dihydroergotamine causes vasoconstriction that opposes nitroglycerin's vasodilation and may worsen myocardial ischemia. Nitrates may also raise ergot bioavailability by reducing its first-pass metabolism, increasing vasospasm risk. Angina patients are particularly at risk.
用白話說明這項交互作用的意義
Dihydroergotamine and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Nitroglycerin belongs to Cardiovascular.
為什麼會發生
Opposing vasoactive effects, with possible increased dihydroergotamine exposure caused by nitrates.
處置方式
Avoid dihydroergotamine in patients needing nitrates for coronary disease and use an alternative migraine therapy. If both are given, monitor for chest pain and ischemic symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Nitroglycerin 的其他交互作用
Dihydroergotamine 的其他交互作用
常見問題
Can I take Dihydroergotamine with Nitroglycerin?
MediHelp rates the interaction as major. Dihydroergotamine and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine causes vasoconstriction that opposes nitroglycerin's vasodilation and may worsen myocardial ischemia. Nitrates may also raise ergot bioavailability by reducing its first-pass metabolism, increasing vasospasm risk. Angina patients are particularly at risk.
How serious is the interaction between Dihydroergotamine and Nitroglycerin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dihydroergotamine in patients needing nitrates for coronary disease and use an alternative migraine therapy. If both are given, monitor for chest pain and ischemic symptoms.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
