藥物交互作用
Azacitidine + Fingolimod
嚴重程度: 嚴重
Azacitidine and Fingolimod: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Azacitidine causes myelosuppression and fingolimod lowers circulating lymphocytes by sequestering them in lymphoid tissue. Together they may increase the risk of serious infection.
用白話說明這項交互作用的意義
Azacitidine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azacitidine belongs to Oncology; Fingolimod belongs to Central Nervous System.
為什麼會發生
Additive immunosuppression: lymphocyte sequestration from fingolimod plus bone marrow suppression from azacitidine.
處置方式
Avoid the combination where possible, or monitor blood counts and infection signs closely. Consider stopping fingolimod during cytotoxic therapy, remembering its immune effects persist for weeks after discontinuation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fingolimod 的其他交互作用
Azacitidine 的其他交互作用
常見問題
Can I take Azacitidine with Fingolimod?
MediHelp rates the interaction as major. Azacitidine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azacitidine causes myelosuppression and fingolimod lowers circulating lymphocytes by sequestering them in lymphoid tissue. Together they may increase the risk of serious infection.
How serious is the interaction between Azacitidine and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood counts and infection signs closely. Consider stopping fingolimod during cytotoxic therapy, remembering its immune effects persist for weeks after discontinuation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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