藥物交互作用
Azacitidine + Denosumab
嚴重程度: 中度
Azacitidine and Denosumab: moderate interaction.
最後更新
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摘要
Denosumab labeling warns of serious infections, including skin infections, in patients with impaired immunity. Azacitidine causes myelosuppression and neutropenia, which adds to infection risk.
用白話說明這項交互作用的意義
Azacitidine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azacitidine belongs to Oncology; Denosumab belongs to Oncology.
為什麼會發生
Additive infection risk: denosumab alters RANKL-mediated immune signalling, while azacitidine suppresses bone marrow function.
處置方式
Monitor for signs of infection and check blood counts regularly. Treat infections promptly and reassess the need for denosumab if serious infections develop.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Denosumab 的其他交互作用
Azacitidine 的其他交互作用
常見問題
Can I take Azacitidine with Denosumab?
MediHelp rates the interaction as moderate. Azacitidine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab labeling warns of serious infections, including skin infections, in patients with impaired immunity. Azacitidine causes myelosuppression and neutropenia, which adds to infection risk.
How serious is the interaction between Azacitidine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts regularly. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
