藥物交互作用
Azathioprine + Denosumab
嚴重程度: 中度
Azathioprine and Denosumab: moderate interaction.
最後更新
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摘要
Denosumab has been associated with serious infections, including skin and urinary tract infections, and the risk may be higher in patients on immunosuppressants. Azathioprine adds to this by suppressing lymphocyte proliferation, so the combination can increase infection susceptibility.
用白話說明這項交互作用的意義
Azathioprine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Denosumab belongs to Oncology.
為什麼會發生
Additive pharmacodynamic effects on immune function; denosumab inhibits RANKL signalling while azathioprine impairs purine synthesis in lymphocytes.
處置方式
Counsel the patient to report fever or signs of infection promptly and treat infections early. Monitor for infection and review the need for continued immunosuppression if serious infections occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Azathioprine 的其他交互作用
Denosumab 的其他交互作用
常見問題
Can I take Azathioprine with Denosumab?
MediHelp rates the interaction as moderate. Azathioprine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab has been associated with serious infections, including skin and urinary tract infections, and the risk may be higher in patients on immunosuppressants. Azathioprine adds to this by suppressing lymphocyte proliferation, so the combination can increase infection susceptibility.
How serious is the interaction between Azathioprine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report fever or signs of infection promptly and treat infections early. Monitor for infection and review the need for continued immunosuppression if serious infections occur.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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