藥物交互作用
Azathioprine + Valoctocogene roxaparvovec
嚴重程度: 中度
Azathioprine and Valoctocogene roxaparvovec: moderate interaction.
最後更新
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摘要
Valoctocogene roxaparvovec commonly causes ALT elevations, and azathioprine can independently injure the liver. Concurrent use may increase the risk or severity of liver enzyme elevations and could confound their interpretation.
用白話說明這項交互作用的意義
Azathioprine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Valoctocogene roxaparvovec belongs to Miscellaneous.
為什麼會發生
Additive hepatotoxicity from the gene therapy's hepatic transduction and immune response and azathioprine's hepatotoxic potential.
處置方式
Monitor liver enzymes closely, as recommended after gene therapy, and consider alternatives to azathioprine where possible. Evaluate promptly for the need for corticosteroids if ALT rises.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Azathioprine 的其他交互作用
Valoctocogene roxaparvovec 的其他交互作用
常見問題
Can I take Azathioprine with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Azathioprine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes ALT elevations, and azathioprine can independently injure the liver. Concurrent use may increase the risk or severity of liver enzyme elevations and could confound their interpretation.
How serious is the interaction between Azathioprine and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely, as recommended after gene therapy, and consider alternatives to azathioprine where possible. Evaluate promptly for the need for corticosteroids if ALT rises.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
