藥物交互作用
Baricitinib + Etrasimod
嚴重程度: 嚴重
Baricitinib and Etrasimod: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs suppress immune function, so using them together may add to the risk of serious infection. Etrasimod lowers circulating lymphocytes and its effect persists for weeks after the last dose. The combination has not been studied.
用白話說明這項交互作用的意義
Baricitinib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Etrasimod belongs to Gastrointestinal Tract.
為什麼會發生
Additive immunosuppression through JAK inhibition and S1P receptor modulation with lymphocyte sequestration.
處置方式
Avoid concurrent use and for several weeks after stopping etrasimod. If unavoidable, monitor closely for infection and check lymphocyte counts.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Baricitinib 的其他交互作用
Etrasimod 的其他交互作用
常見問題
Can I take Baricitinib with Etrasimod?
MediHelp rates the interaction as major. Baricitinib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, so using them together may add to the risk of serious infection. Etrasimod lowers circulating lymphocytes and its effect persists for weeks after the last dose. The combination has not been studied.
How serious is the interaction between Baricitinib and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and for several weeks after stopping etrasimod. If unavoidable, monitor closely for infection and check lymphocyte counts.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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