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藥物交互作用

Baricitinib + Ublituximab

嚴重程度: 嚴重

Baricitinib and Ublituximab: major interaction.

最後更新

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Both drugs suppress immunity, so combined use may increase the risk of serious infections. B-cell depletion from ublituximab lasts well beyond each dose.

用白話說明這項交互作用的意義

Baricitinib and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Baricitinib belongs to Musculoskeletal; Ublituximab belongs to Miscellaneous.

證據等級: Low

為什麼會發生

Additive immunosuppression from JAK inhibition and anti-CD20 B-cell depletion.

處置方式

Avoid concurrent use where possible. If combined, monitor closely for infection signs and review the timing of each therapy.

可向藥師詢問的問題

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Baricitinib 與 Ublituximab 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Baricitinib with Ublituximab?

MediHelp rates the interaction as major. Baricitinib and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immunity, so combined use may increase the risk of serious infections. B-cell depletion from ublituximab lasts well beyond each dose.

How serious is the interaction between Baricitinib and Ublituximab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If combined, monitor closely for infection signs and review the timing of each therapy.

What other medicines interact with Baricitinib?

MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.

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