藥物交互作用
Leflunomide + Ublituximab
嚴重程度: 嚴重
Leflunomide and Ublituximab: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs suppress immune function, so combined use may increase the risk of serious infections. The risk is greater because leflunomide's active metabolite persists for a long time.
用白話說明這項交互作用的意義
Leflunomide and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Leflunomide belongs to Musculoskeletal; Ublituximab belongs to Miscellaneous.
為什麼會發生
Additive immunosuppression from B-cell depletion by ublituximab and lymphocyte antiproliferation by leflunomide.
處置方式
Avoid combining where possible. If used together, monitor closely for infection, and consider the long persistence of teriflunomide, using accelerated elimination if needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Leflunomide 的其他交互作用
Ublituximab 的其他交互作用
常見問題
Can I take Leflunomide with Ublituximab?
MediHelp rates the interaction as major. Leflunomide and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, so combined use may increase the risk of serious infections. The risk is greater because leflunomide's active metabolite persists for a long time.
How serious is the interaction between Leflunomide and Ublituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If used together, monitor closely for infection, and consider the long persistence of teriflunomide, using accelerated elimination if needed.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
