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藥物交互作用

Belladonna and opium + Melatonin

嚴重程度: 中度

Belladonna and opium and Melatonin: moderate interaction.

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僅供醫療專業人員參考。本頁為簡要摘要,並非醫療建議,亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

The opium component causes CNS and respiratory depression, which may be added to by the mild sedative effect of melatonin. Belladonna alkaloids can also cause drowsiness and confusion, especially in older adults.

用白話說明這項交互作用的意義

Belladonna and opium and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

證據等級: Low

為什麼會發生

Additive CNS depression.

處置方式

Monitor for excess sedation and respiratory depression, especially in elderly patients. Lower the opioid dose if needed.

可向藥師詢問的問題

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

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常見問題

Can I take Belladonna and opium with Melatonin?

MediHelp rates the interaction as moderate. Belladonna and opium and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component causes CNS and respiratory depression, which may be added to by the mild sedative effect of melatonin. Belladonna alkaloids can also cause drowsiness and confusion, especially in older adults.

How serious is the interaction between Belladonna and opium and Melatonin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression, especially in elderly patients. Lower the opioid dose if needed.

What other medicines interact with Melatonin?

MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Buprenorphine buccal. The full list is on the Melatonin page.

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