藥物交互作用
Benazepril + Bismuth subsalicylate
嚴重程度: 中度
Benazepril and Bismuth subsalicylate: moderate interaction.
最後更新
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摘要
Salicylate absorbed from bismuth subsalicylate can blunt the blood pressure lowering effect of ACE inhibitors and may add to renal risk, especially in volume depletion, such as during diarrhea. Acute kidney injury is a concern in dehydrated or older patients.
用白話說明這項交互作用的意義
Benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Bismuth subsalicylate belongs to Gastrointestinal Tract.
為什麼會發生
Salicylate-mediated inhibition of renal prostaglandins reduces vasodilation and renal perfusion, antagonizing ACE inhibitor effects.
處置方式
Avoid regular or prolonged use of bismuth subsalicylate. In dehydrated patients monitor renal function, potassium and blood pressure.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Bismuth subsalicylate 的其他交互作用
Benazepril 的其他交互作用
常見問題
Can I take Benazepril with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylate absorbed from bismuth subsalicylate can blunt the blood pressure lowering effect of ACE inhibitors and may add to renal risk, especially in volume depletion, such as during diarrhea. Acute kidney injury is a concern in dehydrated or older patients.
How serious is the interaction between Benazepril and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular or prolonged use of bismuth subsalicylate. In dehydrated patients monitor renal function, potassium and blood pressure.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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