藥物交互作用
Bevacizumab + Sunitinib
嚴重程度: 嚴重
Bevacizumab and Sunitinib: major interaction.
最後更新
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摘要
Combining these two anti-angiogenic agents has led to microangiopathic hemolytic anemia in patients with metastatic renal cell carcinoma. Hypertension and thrombocytopenia have also been seen, which makes the combination poorly tolerated.
用白話說明這項交互作用的意義
Bevacizumab and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bevacizumab belongs to Oncology; Sunitinib belongs to Oncology.
為什麼會發生
Combined inhibition of VEGF signalling at the ligand and receptor tyrosine kinase level causing endothelial injury and microangiopathy; exact mechanism is not fully defined.
處置方式
Avoid concurrent use. If microangiopathic hemolytic anemia is suspected, check hemoglobin, platelets, LDH, haptoglobin and a blood smear, and stop the drugs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bevacizumab 的其他交互作用
Sunitinib 的其他交互作用
常見問題
Can I take Bevacizumab with Sunitinib?
MediHelp rates the interaction as major. Bevacizumab and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining these two anti-angiogenic agents has led to microangiopathic hemolytic anemia in patients with metastatic renal cell carcinoma. Hypertension and thrombocytopenia have also been seen, which makes the combination poorly tolerated.
How serious is the interaction between Bevacizumab and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If microangiopathic hemolytic anemia is suspected, check hemoglobin, platelets, LDH, haptoglobin and a blood smear, and stop the drugs.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Daunorubicin, Dengue vaccine, Doxorubicin. The full list is on the Bevacizumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
