藥物交互作用
Bevacizumab + Doxorubicin
嚴重程度: 中度
Bevacizumab and Doxorubicin: moderate interaction.
最後更新
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摘要
Both agents can impair cardiac function, and bevacizumab may add to anthracycline-related heart failure and left ventricular dysfunction. Bevacizumab also causes hypertension, which adds to cardiac strain. The risk is greater with higher cumulative anthracycline doses or prior cardiac disease.
用白話說明這項交互作用的意義
Bevacizumab and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Doxorubicin belongs to Oncology.
為什麼會發生
Additive cardiotoxicity through anthracycline myocardial injury and VEGF inhibition with associated hypertension.
處置方式
Assess baseline left ventricular ejection fraction and repeat periodically during treatment. Control blood pressure and track the cumulative doxorubicin dose.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Doxorubicin 的其他交互作用
Bevacizumab 的其他交互作用
常見問題
Can I take Bevacizumab with Doxorubicin?
MediHelp rates the interaction as moderate. Bevacizumab and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair cardiac function, and bevacizumab may add to anthracycline-related heart failure and left ventricular dysfunction. Bevacizumab also causes hypertension, which adds to cardiac strain. The risk is greater with higher cumulative anthracycline doses or prior cardiac disease.
How serious is the interaction between Bevacizumab and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess baseline left ventricular ejection fraction and repeat periodically during treatment. Control blood pressure and track the cumulative doxorubicin dose.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
