藥物交互作用
Bictegravir + Magnesium hydroxide
嚴重程度: 中度
Bictegravir and Magnesium hydroxide: moderate interaction.
最後更新
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摘要
Magnesium-containing antacids bind bictegravir in the gut and lower its absorption, which may reduce antiviral efficacy and risk virologic failure or resistance. The effect depends on the timing of the doses.
用白話說明這項交互作用的意義
Bictegravir and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Divalent magnesium cations chelate the integrase inhibitor in the GI tract, reducing absorption.
處置方式
Take bictegravir at least 2 hours before magnesium antacids under fasting conditions. Avoid taking them together or taking the antacid within 2 hours before bictegravir.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Magnesium hydroxide 的其他交互作用
常見問題
Can I take Bictegravir with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Bictegravir and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids bind bictegravir in the gut and lower its absorption, which may reduce antiviral efficacy and risk virologic failure or resistance. The effect depends on the timing of the doses.
How serious is the interaction between Bictegravir and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take bictegravir at least 2 hours before magnesium antacids under fasting conditions. Avoid taking them together or taking the antacid within 2 hours before bictegravir.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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