藥物交互作用
Dolutegravir + Magnesium hydroxide
嚴重程度: 嚴重
Dolutegravir and Magnesium hydroxide: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Magnesium binds dolutegravir in the gut and substantially lowers its absorption. Reduced exposure may cause virologic failure and integrase resistance.
用白話說明這項交互作用的意義
Dolutegravir and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolutegravir belongs to Anti Virals; Magnesium hydroxide belongs to Gastrointestinal Tract.
為什麼會發生
Chelation of dolutegravir by polyvalent magnesium cations in the gastrointestinal tract.
處置方式
Take dolutegravir 2 hours before or 6 hours after magnesium hydroxide. Monitor viral load if timing cannot be maintained.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Magnesium hydroxide 的其他交互作用
Dolutegravir 的其他交互作用
常見問題
Can I take Dolutegravir with Magnesium hydroxide?
MediHelp rates the interaction as major. Dolutegravir and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium binds dolutegravir in the gut and substantially lowers its absorption. Reduced exposure may cause virologic failure and integrase resistance.
How serious is the interaction between Dolutegravir and Magnesium hydroxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir 2 hours before or 6 hours after magnesium hydroxide. Monitor viral load if timing cannot be maintained.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Magnesium hydroxide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
