藥物交互作用
Ciprofloxacin + Magnesium hydroxide
嚴重程度: 嚴重
Ciprofloxacin and Magnesium hydroxide: major interaction.
最後更新
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摘要
Magnesium in antacids chelates ciprofloxacin in the gut and markedly reduces its absorption. This can lead to subtherapeutic antibiotic levels and treatment failure or resistance.
用白話說明這項交互作用的意義
Ciprofloxacin and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Magnesium hydroxide belongs to Gastrointestinal Tract.
為什麼會發生
Chelation of ciprofloxacin by polyvalent magnesium cations in the gastrointestinal tract reduces absorption.
處置方式
Give oral ciprofloxacin at least 2 hours before or 6 hours after magnesium hydroxide. Use a non-cation alternative where possible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Magnesium hydroxide 的其他交互作用
Ciprofloxacin 的其他交互作用
常見問題
Can I take Ciprofloxacin with Magnesium hydroxide?
MediHelp rates the interaction as major. Ciprofloxacin and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium in antacids chelates ciprofloxacin in the gut and markedly reduces its absorption. This can lead to subtherapeutic antibiotic levels and treatment failure or resistance.
How serious is the interaction between Ciprofloxacin and Magnesium hydroxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral ciprofloxacin at least 2 hours before or 6 hours after magnesium hydroxide. Use a non-cation alternative where possible.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Dolutegravir, Gemifloxacin, Levofloxacin. The full list is on the Magnesium hydroxide page.
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