藥物交互作用
Blinatumomab + Sirolimus
嚴重程度: 中度
Blinatumomab and Sirolimus: moderate interaction.
最後更新
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摘要
Blinatumomab causes transient cytokine release that can suppress CYP450 enzymes, mainly in the first days of each cycle. This may transiently raise sirolimus concentrations and cause toxicity.
用白話說明這項交互作用的意義
Blinatumomab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Sirolimus belongs to Miscellaneous.
為什麼會發生
Cytokine-mediated transient suppression of CYP3A4 reducing sirolimus metabolism.
處置方式
Monitor sirolimus trough levels and toxicity during the first days of each blinatumomab cycle. Adjust the sirolimus dose as needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Sirolimus 的其他交互作用
Blinatumomab 的其他交互作用
常見問題
Can I take Blinatumomab with Sirolimus?
MediHelp rates the interaction as moderate. Blinatumomab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes transient cytokine release that can suppress CYP450 enzymes, mainly in the first days of each cycle. This may transiently raise sirolimus concentrations and cause toxicity.
How serious is the interaction between Blinatumomab and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and toxicity during the first days of each blinatumomab cycle. Adjust the sirolimus dose as needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
