藥物交互作用
Levoketoconazole + Sirolimus
嚴重程度: 禁忌併用
Levoketoconazole and Sirolimus: contraindicated interaction.
最後更新
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摘要
Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise sirolimus exposure. This may cause serious toxicity, including myelosuppression, hyperlipidemia, infection and impaired wound healing.
用白話說明這項交互作用的意義
Levoketoconazole and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Sirolimus belongs to Miscellaneous.
為什麼會發生
Strong inhibition of CYP3A4 and P-glycoprotein reduces sirolimus metabolism and efflux.
處置方式
Avoid the combination and use an alternative treatment. If the interaction cannot be avoided, specialist guidance and very close sirolimus level monitoring are needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sirolimus 的其他交互作用
Levoketoconazole 的其他交互作用
常見問題
Can I take Levoketoconazole with Sirolimus?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise sirolimus exposure. This may cause serious toxicity, including myelosuppression, hyperlipidemia, infection and impaired wound healing.
How serious is the interaction between Levoketoconazole and Sirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative treatment. If the interaction cannot be avoided, specialist guidance and very close sirolimus level monitoring are needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
