藥物交互作用
Bromocriptine + Dihydroergotamine intranasal
嚴重程度: 嚴重
Bromocriptine and Dihydroergotamine intranasal: major interaction.
最後更新
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摘要
Intranasal dihydroergotamine is absorbed systemically and combined with bromocriptine may add to ergot-related vasoconstriction, causing hypertension, vasospasm or peripheral ischemia. The combination offers little benefit relative to its risk.
用白話說明這項交互作用的意義
Bromocriptine and Dihydroergotamine intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive pharmacodynamic vasoconstrictive and ergot-related effects at vascular receptors.
處置方式
Avoid the combination and use a non-ergot migraine therapy if bromocriptine is required. If both are used, monitor blood pressure and for signs of ischemia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bromocriptine 的其他交互作用
常見問題
Can I take Bromocriptine with Dihydroergotamine intranasal?
MediHelp rates the interaction as major. Bromocriptine and Dihydroergotamine intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intranasal dihydroergotamine is absorbed systemically and combined with bromocriptine may add to ergot-related vasoconstriction, causing hypertension, vasospasm or peripheral ischemia. The combination offers little benefit relative to its risk.
How serious is the interaction between Bromocriptine and Dihydroergotamine intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-ergot migraine therapy if bromocriptine is required. If both are used, monitor blood pressure and for signs of ischemia.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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