藥物交互作用
Atazanavir + Bromocriptine
嚴重程度: 嚴重
Atazanavir and Bromocriptine: major interaction.
最後更新
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摘要
Atazanavir inhibits CYP3A4, which metabolizes bromocriptine, so bromocriptine concentrations may rise. This can cause nausea, hypotension, headache and other dopaminergic toxicity.
用白話說明這項交互作用的意義
Atazanavir and Bromocriptine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Bromocriptine belongs to Central Nervous System.
為什麼會發生
Inhibition of CYP3A4-mediated bromocriptine metabolism by atazanavir, which reduces clearance.
處置方式
Start bromocriptine at a low dose and titrate cautiously, or choose an alternative dopamine agonist. Monitor blood pressure and for dopaminergic adverse effects.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bromocriptine 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Bromocriptine?
MediHelp rates the interaction as major. Atazanavir and Bromocriptine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4, which metabolizes bromocriptine, so bromocriptine concentrations may rise. This can cause nausea, hypotension, headache and other dopaminergic toxicity.
How serious is the interaction between Atazanavir and Bromocriptine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start bromocriptine at a low dose and titrate cautiously, or choose an alternative dopamine agonist. Monitor blood pressure and for dopaminergic adverse effects.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Cobicistat, Darunavir. The full list is on the Bromocriptine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
