藥物交互作用
Bromocriptine + Elvitegravir / cobicistat / emtricitabine / tenofovir df
嚴重程度: 嚴重
Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
最後更新
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摘要
Cobicistat strongly inhibits CYP3A4, the main route of bromocriptine metabolism, so bromocriptine exposure can increase substantially. Effects include hypotension, nausea, somnolence and possible ergot-type vasospasm.
用白話說明這項交互作用的意義
Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of bromocriptine by cobicistat.
處置方式
Avoid the combination if possible or reduce the bromocriptine dose and titrate slowly. Monitor blood pressure and for symptoms of vasospasm or excess dopaminergic effects.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bromocriptine 的其他交互作用
常見問題
Can I take Bromocriptine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat strongly inhibits CYP3A4, the main route of bromocriptine metabolism, so bromocriptine exposure can increase substantially. Effects include hypotension, nausea, somnolence and possible ergot-type vasospasm.
How serious is the interaction between Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or reduce the bromocriptine dose and titrate slowly. Monitor blood pressure and for symptoms of vasospasm or excess dopaminergic effects.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
