藥物交互作用
Bumetanide + Zoledronic acid
嚴重程度: 中度
Bumetanide and Zoledronic acid: moderate interaction.
最後更新
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摘要
Loop diuretics increase urinary calcium and magnesium loss, which may add to the hypocalcemia from zoledronic acid. Volume depletion from diuresis can also worsen zoledronic acid renal toxicity.
用白話說明這項交互作用的意義
Bumetanide and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Zoledronic acid belongs to Musculoskeletal.
為什麼會發生
Additive lowering of serum calcium through increased renal calcium excretion plus inhibition of bone resorption, with diuretic-related volume depletion.
處置方式
Ensure adequate hydration before zoledronic acid, and monitor serum calcium, magnesium and renal function after infusion.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Zoledronic acid 的其他交互作用
Bumetanide 的其他交互作用
常見問題
Can I take Bumetanide with Zoledronic acid?
MediHelp rates the interaction as moderate. Bumetanide and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics increase urinary calcium and magnesium loss, which may add to the hypocalcemia from zoledronic acid. Volume depletion from diuresis can also worsen zoledronic acid renal toxicity.
How serious is the interaction between Bumetanide and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration before zoledronic acid, and monitor serum calcium, magnesium and renal function after infusion.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Dichlorphenamide, Ethacrynic acid. The full list is on the Zoledronic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
