藥物交互作用
Ethacrynic acid + Zoledronic acid
嚴重程度: 中度
Ethacrynic acid and Zoledronic acid: moderate interaction.
最後更新
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摘要
Zoledronic acid lowers serum calcium and loop diuretics such as ethacrynic acid increase urinary calcium loss. Together they may add to the risk of hypocalcemia, and ethacrynic acid can also add to electrolyte disturbances such as hypomagnesemia.
用白話說明這項交互作用的意義
Ethacrynic acid and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Zoledronic acid belongs to Musculoskeletal.
為什麼會發生
Additive calcium lowering through inhibition of bone resorption (bisphosphonate) and increased renal calcium excretion (loop diuretic).
處置方式
Correct hypocalcemia and vitamin D deficiency before zoledronic acid. Monitor serum calcium and magnesium after dosing and supplement calcium as needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Zoledronic acid 的其他交互作用
Ethacrynic acid 的其他交互作用
常見問題
Can I take Ethacrynic acid with Zoledronic acid?
MediHelp rates the interaction as moderate. Ethacrynic acid and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zoledronic acid lowers serum calcium and loop diuretics such as ethacrynic acid increase urinary calcium loss. Together they may add to the risk of hypocalcemia, and ethacrynic acid can also add to electrolyte disturbances such as hypomagnesemia.
How serious is the interaction between Ethacrynic acid and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypocalcemia and vitamin D deficiency before zoledronic acid. Monitor serum calcium and magnesium after dosing and supplement calcium as needed.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
