藥物交互作用
Buprenorphine subdermal implant + Chlordiazepoxide-clidinium
嚴重程度: 嚴重
Buprenorphine subdermal implant and Chlordiazepoxide-clidinium: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Buprenorphine with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. The implant gives continuous exposure that cannot be quickly withdrawn.
用白話說明這項交互作用的意義
Buprenorphine subdermal implant and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression from opioid and benzodiazepine effects.
處置方式
Use together only when alternatives are inadequate, and keep benzodiazepine dose and duration minimal. Monitor for sedation and respiratory depression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide-clidinium 的其他交互作用
常見問題
Can I take Buprenorphine subdermal implant with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. The implant gives continuous exposure that cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine subdermal implant and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, and keep benzodiazepine dose and duration minimal. Monitor for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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