藥物交互作用
Bupropion + Theophylline
嚴重程度: 嚴重
Bupropion and Theophylline: major interaction.
最後更新 來源: US FDA label
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摘要
Both theophylline and bupropion lower the seizure threshold, so combined use increases the risk of seizures. This is particularly relevant when theophylline levels are elevated or bupropion doses are high.
用白話說明這項交互作用的意義
Bupropion and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Theophylline belongs to Respiratory.
為什麼會發生
Additive pharmacodynamic lowering of the seizure threshold.
處置方式
Avoid the combination when possible, or use the lowest effective bupropion dose with gradual titration. Keep theophylline levels within the therapeutic range and avoid in patients with other seizure risk factors.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
- buPropion Hydrochloride XL - FDA drug label (DailyMed) — openFDA / DailyMed
Theophylline 的其他交互作用
Bupropion 的其他交互作用
常見問題
Can I take Bupropion with Theophylline?
MediHelp rates the interaction as major. Bupropion and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both theophylline and bupropion lower the seizure threshold, so combined use increases the risk of seizures. This is particularly relevant when theophylline levels are elevated or bupropion doses are high.
How serious is the interaction between Bupropion and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, or use the lowest effective bupropion dose with gradual titration. Keep theophylline levels within the therapeutic range and avoid in patients with other seizure risk factors.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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