藥物交互作用
Cimetidine + Theophylline
嚴重程度: 嚴重
Cimetidine and Theophylline: major interaction.
最後更新 來源: US FDA label
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摘要
Cimetidine reduces theophylline clearance and can substantially raise serum levels, risking nausea, tachycardia, arrhythmia and seizures. Theophylline has a narrow therapeutic index so this is clinically important.
用白話說明這項交互作用的意義
Cimetidine and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Theophylline belongs to Respiratory.
為什麼會發生
Cimetidine inhibits CYP1A2 (and CYP3A4), decreasing theophylline metabolism.
處置方式
Prefer an alternative acid suppressant such as famotidine or a proton pump inhibitor. If combined, reduce the theophylline dose and monitor serum concentrations.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
- Theophylline (Anhydrous) - FDA drug label (DailyMed) — openFDA / DailyMed
Theophylline 的其他交互作用
Cimetidine 的其他交互作用
常見問題
Can I take Cimetidine with Theophylline?
MediHelp rates the interaction as major. Cimetidine and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine reduces theophylline clearance and can substantially raise serum levels, risking nausea, tachycardia, arrhythmia and seizures. Theophylline has a narrow therapeutic index so this is clinically important.
How serious is the interaction between Cimetidine and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative acid suppressant such as famotidine or a proton pump inhibitor. If combined, reduce the theophylline dose and monitor serum concentrations.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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