藥物交互作用
Cabozantinib + Nevirapine
嚴重程度: 嚴重
Cabozantinib and Nevirapine: major interaction.
最後更新
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摘要
Nevirapine can reduce cabozantinib concentrations and may lower anticancer efficacy.
用白話說明這項交互作用的意義
Cabozantinib and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabozantinib belongs to Oncology; Nevirapine belongs to Anti Virals.
為什麼會發生
CYP3A4 induction by nevirapine accelerates cabozantinib metabolism.
處置方式
Avoid the combination if possible. If unavoidable, increase the cabozantinib dose per labeling and return to the usual dose a few days after nevirapine is stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Nevirapine 的其他交互作用
Cabozantinib 的其他交互作用
常見問題
Can I take Cabozantinib with Nevirapine?
MediHelp rates the interaction as major. Cabozantinib and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine can reduce cabozantinib concentrations and may lower anticancer efficacy.
How serious is the interaction between Cabozantinib and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, increase the cabozantinib dose per labeling and return to the usual dose a few days after nevirapine is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
