藥物交互作用
Cannabidiol + Tacrolimus
嚴重程度: 嚴重
Cannabidiol and Tacrolimus: major interaction.
最後更新
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摘要
Cannabidiol inhibits CYP3A4 and P-gp and can raise tacrolimus concentrations. This may cause toxicity, including renal impairment and neurotoxicity.
用白話說明這項交互作用的意義
Cannabidiol and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cannabidiol belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
為什麼會發生
Cannabidiol inhibits CYP3A4 and P-glycoprotein, reducing tacrolimus metabolism and efflux.
處置方式
Monitor tacrolimus trough levels and renal function after starting or changing cannabidiol, and reduce the tacrolimus dose as needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tacrolimus 的其他交互作用
Cannabidiol 的其他交互作用
常見問題
Can I take Cannabidiol with Tacrolimus?
MediHelp rates the interaction as major. Cannabidiol and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cannabidiol inhibits CYP3A4 and P-gp and can raise tacrolimus concentrations. This may cause toxicity, including renal impairment and neurotoxicity.
How serious is the interaction between Cannabidiol and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function after starting or changing cannabidiol, and reduce the tacrolimus dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
