藥物交互作用
Amiodarone + Cannabidiol
嚴重程度: 中度
Amiodarone and Cannabidiol: moderate interaction.
最後更新
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摘要
Cannabidiol inhibits several CYP enzymes including CYP2C19 and CYP2C8, and amiodarone may raise cannabidiol levels via CYP3A4 inhibition. Both drugs may reach higher concentrations, increasing adverse effects such as sedation, liver enzyme elevation, bradycardia or QT effects.
用白話說明這項交互作用的意義
Amiodarone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Cannabidiol belongs to Central Nervous System.
為什麼會發生
Bidirectional inhibition of CYP-mediated metabolism (CYP3A4 for cannabidiol; CYP2C8/2C19 for amiodarone).
處置方式
Monitor for sedation, liver function and ECG changes, and consider reducing the cannabidiol dose if adverse effects appear. Adjust amiodarone based on heart rate, QTc and clinical response.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amiodarone 的其他交互作用
Cannabidiol 的其他交互作用
常見問題
Can I take Amiodarone with Cannabidiol?
MediHelp rates the interaction as moderate. Amiodarone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits several CYP enzymes including CYP2C19 and CYP2C8, and amiodarone may raise cannabidiol levels via CYP3A4 inhibition. Both drugs may reach higher concentrations, increasing adverse effects such as sedation, liver enzyme elevation, bradycardia or QT effects.
How serious is the interaction between Amiodarone and Cannabidiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, liver function and ECG changes, and consider reducing the cannabidiol dose if adverse effects appear. Adjust amiodarone based on heart rate, QTc and clinical response.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
