藥物交互作用
Carbidopa-levodopa + Selegiline transdermal
嚴重程度: 禁忌併用
Carbidopa-levodopa and Selegiline transdermal: contraindicated interaction.
最後更新
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摘要
Transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B non-selectively. With levodopa, accumulated catecholamines can precipitate hypertensive crisis.
用白話說明這項交互作用的意義
Carbidopa-levodopa and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Non-selective MAO inhibition blocks catecholamine breakdown, potentiating levodopa-derived dopamine and noradrenaline.
處置方式
Avoid the combination; use another antidepressant or antiparkinsonian regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Carbidopa-levodopa 的其他交互作用
常見問題
Can I take Carbidopa-levodopa with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Carbidopa-levodopa and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B non-selectively. With levodopa, accumulated catecholamines can precipitate hypertensive crisis.
How serious is the interaction between Carbidopa-levodopa and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use another antidepressant or antiparkinsonian regimen.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Carbidopa-levodopa page.
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