藥物交互作用
Amisulpride + Carbidopa-levodopa
嚴重程度: 嚴重
Amisulpride and Carbidopa-levodopa: major interaction.
最後更新
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摘要
Amisulpride blocks dopamine receptors and can counteract the benefit of levodopa, worsening motor symptoms in Parkinson's disease. Levodopa may also reduce the antipsychotic effect.
用白話說明這項交互作用的意義
Amisulpride and Carbidopa-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Carbidopa-levodopa belongs to Central Nervous System.
為什麼會發生
Pharmacodynamic antagonism: D2/D3 receptor blockade by amisulpride opposes dopaminergic stimulation from levodopa.
處置方式
Avoid the combination where possible; if psychosis in Parkinson's disease needs treatment, use clozapine or quetiapine at low doses. Monitor motor function closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbidopa-levodopa 的其他交互作用
Amisulpride 的其他交互作用
常見問題
Can I take Amisulpride with Carbidopa-levodopa?
MediHelp rates the interaction as major. Amisulpride and Carbidopa-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride blocks dopamine receptors and can counteract the benefit of levodopa, worsening motor symptoms in Parkinson's disease. Levodopa may also reduce the antipsychotic effect.
How serious is the interaction between Amisulpride and Carbidopa-levodopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if psychosis in Parkinson's disease needs treatment, use clozapine or quetiapine at low doses. Monitor motor function closely.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
