藥物交互作用
Carbidopa-levodopa + Isocarboxazid
嚴重程度: 禁忌併用
Carbidopa-levodopa and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Severe hypertension, flushing, headache and hyperpyrexia may follow.
用白話說明這項交互作用的意義
Carbidopa-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-levodopa belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines
處置方式
Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Carbidopa-levodopa 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Carbidopa-levodopa with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Carbidopa-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-levodopa and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Phenelzine, Selegiline transdermal, Tranylcypromine. The full list is on the Carbidopa-levodopa page.
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