藥物交互作用
Carbimazole + Rosuvastatin
嚴重程度: 中度
Carbimazole and Rosuvastatin: moderate interaction.
最後更新 來源: US FDA label
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摘要
Carbimazole treats hyperthyroidism and can overshoot into hypothyroidism if the dose is excessive. Hypothyroidism is a recognised risk factor for statin-associated myopathy and rhabdomyolysis, so muscle toxicity from rosuvastatin may be more likely during periods of low thyroid function. The interaction is indirect and depends on thyroid status.
用白話說明這項交互作用的意義
Carbimazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbimazole belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
為什麼會發生
Pharmacodynamic and indirect: drug-induced hypothyroidism predisposes to statin myotoxicity. No direct CYP or transporter interaction is expected.
處置方式
Check thyroid function before starting or increasing rosuvastatin and aim for euthyroidism. Monitor thyroid function regularly after carbimazole dose changes and adjust carbimazole if TSH rises.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
- Crestor (rosuvastatin calcium) Prescribing Information - Warnings and Precautions: Myopathy and Rhabdomyolysis — FDA Label
- Neo-Mercazole (carbimazole) Summary of Product Characteristics — EMA SmPC
Carbimazole 的其他交互作用
Rosuvastatin 的其他交互作用
常見問題
Can I take Carbimazole with Rosuvastatin?
MediHelp rates the interaction as moderate. Carbimazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbimazole treats hyperthyroidism and can overshoot into hypothyroidism if the dose is excessive. Hypothyroidism is a recognised risk factor for statin-associated myopathy and rhabdomyolysis, so muscle toxicity from rosuvastatin may be more likely during periods of low thyroid function. The interaction is indirect and depends on thyroid status.
How serious is the interaction between Carbimazole and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check thyroid function before starting or increasing rosuvastatin and aim for euthyroidism. Monitor thyroid function regularly after carbimazole dose changes and adjust carbimazole if TSH rises.
What other medicines interact with Carbimazole?
MediHelp also lists interactions of Carbimazole with, for example, Tiratricol. The full list is on the Carbimazole page.
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